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What Is Modafinil Drug?

What Is Modafinil Drug

Modafinil is a prescription drug used as a remedy to sleep disorder conditions. Due to its impressive benefits, various people from all walks of life have used it off-label to promote wakefulness, increase productivity, and to enhance cognitive function. It’s not a surprise why professionals secretly use it to win a competition but can modafinil make you smart in studying?

This will help you understand what modafinil tablets are, its use and benefits, dosage recommendation, contraindication, and caution, as well as the best online pharmacy to source generic modafinil including free trial samples.

What Is Modafinil Medication?

Modafinil is an active ingredient used in various medicines both as a generic or a brand-name drug. Cephalon, Inc. is an American company that was approved by the Food and Drug Administration (FDA) in 1998 to manufacture modafinil medication under the trade-name Provigil®.

Still, the FDA has given these pharmaceutical manufacturers approval to produce generic Provigil:

  • Alembic Pharmaceuticals Limited approved on October 18, 2012;
  • Appcco, approval date: August 16, 2017;
  • Apotex Inc. approved on February 3, 2014;
  • Mylan Pharmaceuticals Inc. approved on July 16, 2012, and others [1].

Modafinil is a Schedule IV controlled substance in the USA. With the patent expiry in some countries, other reputable pharmaceutical companies emerged producing generic modafinil medicine. Core reason? To address the higher cost of Provigil® – to more than 90% cheaper and make the drug easily available to individuals who have been prescribed this medication.

For this reason, reputable and trusted modafinil generic manufacturers include:

  • Sun Pharma – an Indian multinational pharmaceutical company providing Modalert & Waklert;
  • HAB Pharma – India. It makes excellent products – including modafinil and armodafinil – Modvigil & Artvigil;
  • INTAS Pharma – an Indian pharmaceutical giant. Makes Modafil MD;
  • Healing Pharma – a pharmaceutical company from India, maker of Modaheal “smart drug.”

Generic modafinil has the same chemical properties just like Provigil®. The only major difference is pricing. The benefits are the same. Being generic does not equate to drug low quality or ineffective. Modafinil’s patent expiry opens the highly anticipated opportunity for other trusted manufacturers to produce the same drug (as generic) without compromising quality and chemical components.

While modafinil is FDA-approved used for excessive daytime sleepiness associated with narcolepsy, obstructive sleep apnea (OSA), and shift work disorder (SWD), many physicians are prescribing it for patients who do not suffer from one of these conditions but exhibit similar symptoms.

Modafinil is being prescribed to patients for “off-label” or “lifestyle” uses, including chronic fatigue syndrome, major depressive disorder, attention deficit hyperactivity disorder (ADD/ADHD), Alzheimer’s disease, depression, multiple sclerosis-induced fatigues, cognitive impairment in schizophrenia, methamphetamine abuse, age-related memory decline, apathy in the elderly, jet-lag, fatigue and other related conditions due to its ability to improve concentration, focus & restore wakefulness among other modafinil benefits.

Dubbed as the world’s first safe “smart drug,” several people use it off-label due to its cognitive-enhancing effects. It’s a safe drug that boosts cognition & helps people from all walks of life improve productivity at work or school.

Effects and Benefits of Modafinil Pills

Modafinil Pills

Outside of prescribed use, modafinil medication is known to be safe and works well especially in healthy people. It’s not just used as a wakefulness-promoting agent. It does more in rewarding those using achieve more in cognition, thinking, during sports, long missions that require wakefulness, during complex tasks that require cognitive power, energy, and vigilance among other related benefits due to modafinil effects. That’s why students and executives – notably CEO’s and professionals use it.

It’s a potent drug useful for long, enduring periods of work (that’s why military & astronauts use it for long missions), or while performing repetitive tasks – up to about 15 hours. Modafinil effectively facilitates reasoning, improves reasoning when it comes to problem-solving, enhances mental performance, energy, and promotes wakefulness and focus [2].

To several people either taking it during college or university to enhance their study performance, most people wonder if it makes them smarter. Yes, modafinil can give an individual an extra boost during complex work or studying. Being safe and tolerable, it has emerged as the ultimate beneficial drug for studying, improving productivity, and promoting wakefulness. Most notable, individuals using modafinil can work longer on a day when taking it. As a fact, an individual can remain active since modafinil’s effective elimination half-life is about 15 hours [3][4].

How Does This Smart Drug Work?

Modafinil has been studied as an active ingredient containing two components. It’s considered as a racemic compound because it is composed of R-(−) and S-(+)-enantiomers (R-modafinil and S-modafinil). The R-enantiomer (medically known as armodafinil is an active ingredient) has unique pharmacological properties. R-(−)-modafinil is extremely stable metabolically & it is a longer-acting enantiomer [5].

R-modafinil is a unique dopamine uptake inhibitor with potential benefits as a remedy for psychostimulant abuse. It binds to the dopamine active transporter (DAT) and inhibits dopamine uptake.

Truth is R-modafinil has a higher affinity than it’s S-enantiomer. Modafinil pharmacology raises the number of dopamine concentrations. It functions by raising the level of dopamine concentrations in the brain by binding to the DAT & inhibits the dopamine reuptake. Dopamine is a chemical neurotransmitter that the brain nerves use to effectively communicate with each other. It also increases the activity of other essential neurotransmitters such as orexin, histamine, and norepinephrine.

By boosting dopamine concentrations in some brain regions, it rewards with effects such as increased blood flow, promotes wakefulness, vigilance, & alertness, and improves energy, memory, focus, & brain executive functioning among other beneficial effects.

That’s the reason why some pharmaceuticals companies have specialized in making generic armodafinil drugs. As to what type of drug you need, it’s best to understand which medicine is made of this active substance. Notably, “smart drugs” containing armodafinil include Artvigil from HAB Pharma and Waklert by Sun Pharma.

The FDA also approved another trade name Nuvigil® by Cephalon Inc. in 2007 as an enantiopure compound of the eugeroic modafinil (Provigil®) [6].

To most patients, modafinil is better prescribed for conditions involving excessive sleepiness. However, this “smart drug” is also used to overcome the symptoms of ADHD among other related conditions by boosting dopamine concentrations in the brain and promoting wakefulness [7]. To healthy individuals without sleep disorder conditions, modafinil remains the world’s first safe “smart drug” used to enhance productivity and promote individual cognitive power if used properly.

Is It Safe for Everyone?

Safe Pills

Modafinil is generally considered safe for most people – highly tolerable with minor side effects. Is it safe to take nootropic in the long-term? The long-term safety of modafinil is not well established and not known.

Unlike most psychiatric medications, modafinil’s safety in regards to negative effects does not build up over time. The medication lasting effects only last for the day (from 10-15 hours) that you take it and can safely be administered as needed or every day depending on the reason you are taking it. Being dubbed as the “world’s first safe smart drug” by researchers at Harvard and Oxford universities, they suggested that modafinil effects are “low risk” especially when taken in the short term. However, like any medicine, negative effects can occur – that come and fade away with drug continual use [7].

Interesting, being safe for healthy individuals, students and professionals just want to achieve a competitive edge – they want to do better at learning and exams and most impressively there is a group of some individuals taking modafinil with the realms to function the best they can all the time [8].

Modafinil can be used by anyone, who wishes to stay awake, work late, enhance their cognitive reactions, or brighten their moods and beat depression and stress among others [9]. With all these benefits, however, to exercise drug safety and enhance its benefits, do not self-medicate, but it’s highly recommended to consult a doctor. What if it doesn’t work? Note that depending on your health, modafinil can be highly beneficial to you or if taken without recommendation, it can cause some unwelcome side effects based on your health, dosage, lifestyles, or drug interactions.

Although it’s safe, people can experience mixed results due to their mode of dosage. With continual long-term use, some individuals have experienced mixed results due to modafinil overdose and dependence. People are concerned if it can affect their sexual behavior.

One individual developed an interesting side effect. He increased the dose of modafinil from 400-1000 mg/day as a remedy to bipolar affective disorder while in remission. The man had hypersexuality. Scientists suggested that modafinil dependence at higher doses can occur leading to modafinil induced hypersexuality and other effects. From this study, though the user had no improvement in his mood, there was a change in his sexual behavior. On seeing any women nearby, he started to have a spontaneous erection and feel excited. Due to this report, and no comprehensive study on modafinil abuse, there can exist a case of modafinil dependence [10].

How to Take Modafinil for Better Results?

Like any medicine, modafinil is taken according to individual health and purpose of use. As a prescription, it’s better to take modafinil according to the medical specialist prescription. Off-label use of nootropic is highly recommended to first consult with a doctor – to assess your health, consider the purpose of use, and provide a safe prescription for better results.

Here is how to take a “smart drug” safely for better results for studying and treating ADHD and shift work sleep disorder.

Dosage of Modafinil for Students

Modafinil is a nootropic or more specifically the “king” of the study drugs. Do not self-medicate in any case if using it off-label. Students take eugeroics to improve their study energy, focus, vigilance, thinking, mental acuity, & concentration to excel during exams or win a competition.

Modafinil 100 – 200 mg tablet is the recommended dose to be taken once per day 45 min. – 1-hour when you’re preparing for an exam or a particular study task such as complex tasks that ultimately require focus and higher cognitive function.

As to how to increase modafinil effects while studying, it depends on how you take it and for what purpose. Some students can increase the dosage to 400 mg max.

With its impressive mechanism of action, It works through several different pathways in the brain that culminate together to boost the entire process of studying. It affects the higher-brain functions that rely on contribution from multiple simple cognitive processes that help students study well with improved memory, thinking, and help them pass in a tough competition that necessarily requires a higher cognitive function.

Take Modafinil

For studying, the best way, use modafinil when you are well rested to ensure your brain is in optimal condition. Ensure you have eaten breakfast and pack some nutritious snacks with you to eat it throughout the day while under the modafinil effect.

It’s not a daily, morning, or evening dose. The best time is to take modafinil when you’re ready for studying – some minutes earlier before a planned study task for the effects of the medicine to begin. Faster effects are achieved in 1-2 hours when taken on an empty stomach with water. Fatty food delays its onset.

Some students find this too stimulating and choose to cut the pills in half. They may also opt for an armodafinil version in the dose strength of 150 mg. Students taking modafinil for the first time may opt to take lower doses and increase it depending on the drug efficacy and tolerability.

Dosage of Modafinil for ADHD Treatment

Due to increased interest in modafinil as a treatment for ADHD. It is often preferred over ADHD/ADD alternatives because of modafinil usage less likely to result in tolerance and addiction.

Just like being used as an off-label purpose on individuals from all walks of life to boost productivity and enhance their cognitive power, modafinil is considered “off-label” in the United States because it hasn’t yet been approved by the FDA for this use.

Modafinil work in a similar way to other common ADHD medications such as Ritalin and Adderall. Individuals with ADHD have issues with sufficient dopamine levels and modafinil can ultimately help get positive feedback in the reward center of the brain.

Using Modafinil for ADHD is taken according to the doctor’s prescription. Doses of either 100 mg or 200 mg are taken by adults to offset the symptoms of ADD or ADHD and increase concentration [11].

It’s taken once daily (in 24 hours). Most people with ADHD take it periodically as they need it. The benefits of taking eugeroic periodically (1-4 times per week) is that it can significantly reduce the chances of developing tolerance to the medication.

Dosage of Modafinil for Shift Work

As a remedy to narcolepsy & OSA, modafinil is taken once daily in the morning. However, modafinil 200 mg as the recommended dosage is taken an hour earlier in individuals with a shift-work sleep disorder (SWD) when preparing for work – same as those taking as a cognitive enhancer to boost productivity, & get complex work done.

Treatment with 200 mg of modafinil for shift work reduced the extreme sleepiness observed in patients with SWSD as it results in a significant improvement in performance [12].

Can You Use This Medicine Every Day?

As a prescription, it is used according to the doctor’s recommendation. A medical specialist can prescribe modafinil to be used daily to sleep disorder conditions. If taking modafinil as a remedy to shift work sleep disorder, you will need to take it 1 hour before the beginning of your work shift for a longer period until you are done with the work sleep disorders that affect you.

If you are taking modafinil to medicate narcolepsy, ADHD/ADD or OSA among other conditions, you will need to take it in the morning every day for a time your doctor recommends. Of most concern is whether modafinil is taken long-term. Is there any modafinil long-term negative effects? This depends on how often you take this medication.

The fact is: Modafinil is generally well-tolerated at high doses of 400 mg maximum or lower. Several in-depth studies have concluded that there is no risk of developing a tolerance for modafinil for everyday long-term use [13]. However, as a recommendation, it’s better to stop nootropic use if the symptoms you were using it for resolved [14].

Possible Side Effects of Modafinil

Side Effects

Although it’s a potent “smart drug” used by several million people globally, modafinil is safe & well tolerated but side effects cannot be fully ruled out. The severity of side effects does not affect everyone. It can be associated with minor, moderate, or major negative effects depending on your health, reaction to the medication, adherence to dosage as well as drug mixing resulting in interaction.

Modafinil’s less serious side effects are not long term. It can last for a few days, hours, or minutes and fades away with continual use of medication. Its common negative effects include:

  • a stuffy and runny nose;
  • diarrhea;
  • difficulty sleeping;
  • head pain;
  • indigestion;
  • anxious feelings;
  • backache;
  • dizziness;
  • nausea;
  • nervousness.

Infrequent side effects that tend to have a severe expression include:

  • change in vision;
  • persistent sleepiness;
  • dyskinesia;
  • memory loss;
  • depression;
  • abnormal heart rhythm;
  • an inability to empty the bladder;
  • chest pain;
  • lazy eye;
  • mood changes;
  • chills;
  • psychiatric symptoms;
  • fast heartbeat;
  • fever;
  • confusion;
  • high/low blood pressure;
  • throat irritation;
  • serious rash (Stevens-Johnson Syndrome).

This is not a complete list. Some individuals can experience RARE negative effects that need immediate medical specialist help [15]. As a precaution, modafinil is likely to cause dizziness or blurred vision. Don’t drive or operate heavy machinery after taking modafinil. Also, it recommended not to stop the modafinil medication suddenly – it can contribute to withdrawal symptoms.

Modafinil has not been studied enough for use in pregnant women. Consulting with a doctor before breastfeeding is necessary.

Interactions With Food, Alcohol, Other Meds

Like any medicine, interaction with food, alcohol, and other medicine you are using can occur. This is the ultimate reason not to self-medicate with any drug including modafinil or mix modafinil with other drugs.

It’s very important to consult with a doctor before trying this “smart pill.” Doctors’ advice is necessary for a safe dosage of this drug to avoid its interaction with other meds that can potentially harm your health with adverse negative effects.

Modafinil Interaction With Other Drugs and Alcohol

You are safe and ready to reap the beneficial effect of modafinil – be it to promote wakefulness, boost productivity, or cognitive power if you have a healthy body and keen on adhering to its dosage and contraindication.

Several medicines may interact with modafinil, such as Inderal or Propranolol, Sandimmune, Cyclosporine/ Neoral, Rifampin/Rifadin, Rimactane, as well as antifungal medications.

Other medications that may cause interaction with modafinil to include:

  • isocarboxazid, phenelzine, selegiline, rasagiline, or tranylcypromine;
  • seizure medication such as carbamazepine, phenytoin, or phenobarbital;
  • Phenytoin (Dilantin), carbamazepine, or phenobarbital;
  • amitriptyline, imipramine, nortriptyline (Pamelor), doxepin, and others;
  • antidepressants such as nortriptyline (Pamelor), doxepin (Sinequan), amitriptyline (Elavil, Etrafon), imipramine (Janimine, Tofranil), and others;
  • a sedative such as midazolam, diazepam, or triazolam;
  • an MAO inhibitor.

This is not a comprehensive list. Follow the instructions given in the leaflet. Make sure to let a doctor give you an “OK” when mixing other drugs with modafinil. It’s however best not to combine it with certain drugs that can harm your health [16][17].

No Alcohol

Do not use alcohol while under modafinil since it is unknown how this will affect you. Modafinil & alcohol have opposite effects on individual brain chemistry. Alcohol unexpectedly can boost the activity of the neurotransmitter – gamma-Aminobutyric acid (GABA) and reduces the action of glutamate. Any modafinil drug is a GABA antagonist that decreases GABA production and boosts glutamate production. To ensure you safely administer modafinil, do not mix with alcohol. It can lead to unprecedented side effects.

Modafinil With Food

Modafinil is safe if taken with food. It is usually taken once a day with or without food or on an empty stomach. Fatty meals may delay the “smart drug” onset of action. However, to reduce the duration of its onset of action, most people take it sublingually (by placing modafinil under the tongue), or by swallowing the tablet on an empty stomach. This allows quick absorption of the active ingredient either modafinil or armodafinil.

Also, taking grapefruit or grapefruit juice can cause some unprecedented side effects if mixed with modafinil.

While taking this nootropic, it’s best to dose safely to achieve peak effects that are well-tolerated. At best, adhere to the doctor’s prescription. Depending on individual health, disease interaction can occur. Let a doctor assess if you have conditions such as liver, kidney or heart problems among others – dose adjustment can be recommended especially dose adjustment in patients with severe hepatic impairment required to take the lower dose of 100 mg unlike patients with normal hepatic function.

What Is the Best Place to Get Trial Generic Modafinil OTC?

When buying modafinil pills online, it’s necessary to get it from a legit and trusted online drugstore. Note that fake vendors can exist selling low quality or counterfeit modafinil generics & other over-the-counter medication.

FreeModafinil is an online modafinil and armodafinil pills vendor that is legit and highly trusted. Provigil® is priced extremely high compared to generics that are sold at 90% cheaper than Provigil’s price. Among other legit e-pharmacies, FreeModafinil is the ultimate e-pharmacy that offers nootropics at the manufacturing cost in addition to various price-reducing experiences.

Shopping for modafinil & armodafinil products (like Waklert, Artvigil, Modvigil, Modafil MD, Modafresh, etc.) from our store gives you a lot of benefits including:

At FreeModafinil online nootropic pharmacy, we source nootropic meds from approved manufacturers including Sun Pharma, INTAS Pharma, HAB pharma, and Healing Pharma making us the best vendor for quality and safe modafinil tablets. The pricing is based on the manufacturing cost.

We love what we do. Our products are genuine – that’s why we give you free trial samples to test our nootropic effectiveness before buying bulk orders. All the eugeroics available from our e-drugstore are safe and worked impressively for healthy individuals.

And that’s not all! Our shipping is worldwide – to most countries except a few listed destinations we do not ship to. Nonetheless, in some instances (very rare), if your parcel gets lost or stuck in customs we offer you free reshipment or a 100% money-back guarantee.

If looking for the best place to buy modafinil, our e-drugstore is your ultimate best for all things modafinil and extras.

References:

  1. Generic Provigil Availability. Retrieved: March 30, 2020. Ddrugs.com.
  2. Modafinil. Retrieved: March 12, 2020. Drugs.com.
  3. Practical Use and Risk of Modafinil, a Novel Waking Drug. By Dongsoo Kim. Published: Feb 22, 2012. Ncbi.nlm.nih.gov.
  4. “Smart Drug” Modafinil Actually Works, Study Shows. By Laura Geggel. Published: August 19, 2015. Livescience.com.
  5. R-MODAFINIL (ARMODAFINIL): A UNIQUE DOPAMINE UPTAKE INHIBITOR AND POTENTIAL MEDICATION FOR PSYCHOSTIMULANT ABUSE. Claus J. Loland, Maddalena Mereu, […], and Amy Hauck Newman. Published online: 2012 Apr 25. Ncbi.nlm.nih.gov.
  6. Armodafinil. Retrieved: 30 March 30, 2020. Wikipedia.org.
  7. Modafinil: A Review of Neurochemical Actions and Effects on Cognition. Michael J Minzenberg & Cameron S Carter. Published: 22 August 2007. Nature.com.
  8. Is modafinil safe in the long term? By David Cox. Published: Fri 31 May 2013. Retrieved: March 30, 2020. Theguardian.com.
  9. Practical Use and Risk of Modafinil, a Novel Waking Drug. Dongsoo Kim. Published online: Feb 22, 2012. Ncbi.nlm.nih.gov.
  10. Modafinil Dependence and Hypersexuality: A Case Report and Review of the Evidence. Sahoo Swapnajeet, BN Subodh, and Gupta Gourav. Published online: 2016 Nov 30. Ncbi.nlm.nih.gov.
  11. A review of the use of modafinil for attention-deficit hyperactivity disorder. Turner D. Published: April 2006. Ncbi.nlm.nih.gov.
  12. Modafinil for Excessive Sleepiness Associated with Shift-Work Sleep Disorder. Charles A. Czeisler, Ph.D., M.D., James K. Walsh, Ph.D., and others. Published: August 4, 2005. Nejm.org.
  13. Long-term efficacy and safety of modafinil (PROVIGIL(R)) for the treatment of excessive daytime sleepiness associated with narcolepsy. Merrill Mitler, John R Harsh, Christian Guilleminault, Max Hirshkowitz. Published: July 2000. Researchgate.net.
  14. Modafinil (pdf). Retrieved: March 12, 2020. Moodtreatmentcenter.com.
  15. Modafinil Side Effects by Likelihood and Severity. Retrieved: March 30, 2020. Webmd.com.
  16. Modafinil. Drug Interactions. Retrieved: March 30, 2020. Drugbank.ca.
  17. PROVIGIL® (modafinil) Tablets [C-IV] (PDF). Retrieved: March 30, 2020. Accessdata.fda.gov.
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We offer several brands of modafinil to choose from. Modvigil is the most cost-efficient brand of modafinil and is our best selling generic. Modalert is the generic of Provigil and is extremely popular. We also offer Modafresh, Artvigil (like Nuvigil), Vilafinil, and Modaheal. We also carry Waklert, a generic version of armodafinil.

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